左室肥厚对急性心肌梗塞时心肌酶的影响

通过２０例有左室肥厚和２３例无左室肥厚患者发生急性心肌梗塞时ＣＰＫ值的比较，发现在梗塞部位相同的情况下，心肌肥厚组的酶值水平高于非心肌肥厚组（１３．２±４．８比９．０±４．６Ｕ／ＬＰ＜０．０１），这可能与肥厚组酶活力增强和心肌梗塞体积增大有关。     

Ca antagonist ameliorates glomerular injury via suppression of glomerular hypertrophy in spontaneously hypertensive rats

Summary: A study was conducted to determine whether calcium blockers (CCB) have renoprotective effects, and if so to elucidate the mechanisms of such effects.
A total of 30 uninephrectomized (UNX) spontaneously hypertensive rats (SHR), 5 weeks of age, were divided into three groups. Group 1 was fed a diet containing 0.01% manidipine and 8% NaCl, while groups 2 and 3 were fed diets containing only 8 and 0.5% NaCl, respectively. Feeding of these diets began 7 days after UNX (experimental day 0). Bodyweight, urinary protein /24 h, urinary sodium excretion/24 h, and food intake were measured at certain time intervals.
At time of death (day 9 or 21), estimations of inulin clearance (Cin) and morphological evaluations, determination of glomerular sclerosis index (GSI), tubulointerstitial index (TII) and glomerular volume were performed.
Urinary protein was significantly higher in groups 1 and 2 than in group 3 from day 7 onward, but did not differ between the former two groups. Cin in group 2 was higher than in groups 1 and 3 on day 9, but declined to lower levels than in groups 1 and 3 by day 21. There was no difference in Cin between group 1 and group 3 on day 21. Morphometry (GSI and TII) revealed that renal lesions were more progressive in group 2 than in group 1. Glomeruli in group 2 were markedly larger than those in group 1, but no difference in glomerular volume was noted between groups 1 and 3.
Our findings suggest that CCB prevent progression of renal injury induced by accelerated hypertension in UNX SHR. the mechanisms of prevention may, at least in part, be related to suppression of glomerular hypertrophy. Inhibition of renal injury can be achieved without significant reduction of proteinuria.     

经直肠彩色多普勒诊断良性前列腺增生37例

目的：探讨经直肠彩色多普勒超声对良性前列腺增生的诊断价值。方法：采用经直肠彩色多普勒对37例良性前列腺增生患者进行检查，测量大小，计算体积，并按前列腺重量分成四组，测定、分析增生内腺动脉的血液动力学参数。分组评价增生内腺的彩色血流图。结果：随前列腺重量的增加，增生内腺血流分布逐渐增加，血流的最大流度(Vmax)、血流最低流速(Vmin)、血流阻力指数(RI)、搏动指数(PI)逐渐增加。结论：经直肠彩色多普勒检查有助于临床对前列腺增生的准确诊断。     

前列腺癌PCNA及AgNOR的表达及临床意义

应用免疫组化（ABC法）和银染技术检测10树前列腺癌和20例前列腺增生患者增殖细胞核抗原（PCNA）和核仁组成区嗜银蛋白（AgNOR）数量变化．结果显示PCNA阳性检出率及AgNOR计数有显著差异（P＜0．01）．且随肿瘤分级增高而增高．随访资料显示PCNA强级（～）者，AgNOR计数高者预后明显低于PCNA弱级（～），AgNOR计数低者．结果提示PCNA，AgNOR可作为前列腺良恶性肿瘤鉴别诊断指标之一，并且与前列腺癌恶性程度有关，对推测预后具有重要参考价值。     

特殊型前列腺增生症的诊治

收治特殊型前列腺增生症１１０例，分别伴有逼尿肌无力、不稳定性膀胱、前列腺结石、膀胱结石、前列腺炎或糖尿病。认为：治疗前认真检查发现特殊前列腺增生症，是提高治愈率、减少并发症的关键步骤之一。     

高血压病左室肥厚与QTc离散度关系的研究

目的 探讨高血压病病左室肥厚（ＬＶＨ）与非在室肥厚（ＮＬＶＨ）患者ＱＴｃｄ的关系及临床意义。方法 用分层抽样法测定１０３例原发性高血压病患者住院首次１２导联心电图ＱＴｃ离散度（ＱＴｃｄ）其中合并ＬＶＨ患者５７例，合并ＮＬＶＨ患者４６例，并与２０例健康人作对照，结果 ＱＴｃｄＬＶＨ组分别与ＮＬＶＨ组，对照组比较均有非常显著性差异（Ｐ〈０．０１）ＮＬＶＨ组与对照组比较无显著性差异（Ｐ〉０．０５）。结论     

Could Chronic Mesenteric Originated Hypoxia Insult Produce Opposite Pathologic Features： Hypoplasia and Hyperplasia of the Intestine

Chronic ischemia produces corresponding tissue hypoplasia. However, here we report a distinctive hypertrophy of the intestine due to chronic mesenteric insufficiency, which was confirmed by angiography in two patients with opposite characteristic pathologic presentation of intestine. During surgery of the first patient, an approximately 60cm long ileum with sausage consistency and cyanosis color was identified proximal to the caecum; wall-attached thromboembolism material and the hypertrophied segment of ileum were removed. In the other patient, the intestine wall was paper thin; after aorto-mesenteric bypass the intestine wall grew thicker. Post operative recovery of both patients was uneventful. The commonly observed situation after a long-standing hypoxic insult in a setting of chronic mesenteric ischemia is that the target tissue will at least develop a slight hypoplasia. However, the cases we present here had either pronounced hyperplasia or severe hypoplasia. We thus report it, expecting to identify a special mechanism to explain this paradox.     

鼻内镜下等离子射频治疗儿童腺样体肥大60例分析

目的探讨鼻内镜下运用等离子治疗仪行腺样体射频减容的优点。方法分析60例腺样体肥大儿童接受等离子手术前、后的临床资料,并对术前术后听力、夜间打鼾、鼻塞等症状恢复情况进行观察比较。结果术后腺样体明显缩小,A/N值小于0.6,鼻咽部结构显示良好,无咽鼓管损伤等并发症发生。随访1~2年,患儿症状消失或明显减轻,治疗有效率为100%。结论鼻内镜下运用等离子射频减容手术治疗腺样体肥大是一种安全有效、简单易行的手术方法,值得推广。     

Effect of prolonged inhibition of neutral endopeptidase on cardiac hypertrophy in rats with myocardial infarction

Summary Myocardial infarction was induced in rats by ligation of the left coronary artery. Treatment with TM1, a prodrug of SQ 28,603, an inhibitor of neutral endopeptidase (NEP, EC 3.4.24.11), was started 18–20 hours after ligation and was continued for 4 weeks (100 mg/kg, orally, twice daily). Morphological and biochemical parameters were assessed at the end of therapy. The treatment resulted in a significant reduction of heart hypertrophy, which was restricted to the parts of myocardium hemodynamically upstream of the infarcted left ventricle. The weights of the right ventricle and atria were reduced by 15–20%, whereas the treatment had no effect on the left ventricle and septum weights. Treatment led to an almost complete inhibition of plasma NEP activity and to a slight decrease (-14%, p<0.05) in plasma ACE activity. Plasma ANF level increased 3.8-fold after ligation, and treatment resulted in a slight (+29%) and nonsignificant additional increase in the ANF level. The amount of hydroxyproline in the right ventricle was enhanced by +207% in control ligated rats and by +140% (NS) in treated rats. These data indicate that prolonged NEP inhibition exerts a favorable effect in heart failure by reducing the development of right ventricular and atrial hypertrophy. These effects may result from an improvement in hemodynamic conditions, leading to a reduction in cardiac preload.     

良性前列腺增生组织中一氧化氮合酶活性的变化

为探讨一氧化氮（ＮＯ）与良性前列腺增生（ＢＰＨ）发病的关系，应用双波长分光光度法测定１５例正常前列腺及２５例ＢＰＨ组织中一氧化氮合酶（ＮＯＳ）活性，并比较不同年龄组的正常前列腺及ＢＰＨ组织中ＮＯＳ活性水平。结果：ＢＰＨ组织中ＮＯＳ活性（９６．７７±２８．０２ｐｍｏｌ．ｍｇ－１．ｍｉｎ－１）明显低于正常前列腺者（２９０．９９±１３０．６８ｐｍｏｌ．ｍｇ－１．ｍｉｎ－１），Ｐ＜０．００１。不同年龄组的正常前列腺组织中ＮＯＳ活性水平与年龄无相关关系。而在５０岁、６０岁和≥７０岁三个年龄组之间的ＢＰＨ组织中ＮＯＳ活性水平有显著性差异，Ｐ＜０．０１，ＢＰＨ组织中ＮＯＳ活性水平随年龄增大呈下降趋势。结果提示前列腺组织中ＮＯＳ活性水平与ＢＰＨ有相关关系，ＮＯＳ活性降低可能是ＢＰＨ的年龄依赖性发病原因之一。